CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs

@inproceedings{Putku2014CDH13PS,
  title={CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs},
  author={Margus Putku and Mart Kals and Rain Inno and Silva Kasela and Elin Org and V. Kozich and Lili Milani and M. ter Laan},
  booktitle={Human Genetics},
  year={2014}
}
CDH13 encodes T-cadherin, a receptor for high molecular weight (HMW) adiponectin and low-density lipoprotein, promoting proliferation and migration of endothelial cells. Genome-wide association studies have mapped multiple variants in CDH13 associated with cardiometabolic traits (CMT) with variable effects across studies. We hypothesized that this heterogeneity might reflect interplay with DNA methylation within the region. Resequencing and EpiTYPER™ assay were applied for the HYPertension in… CONTINUE READING
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