CDH13 and FLBN3 Gene Methylation are Associated with Poor Prognosis in Colorectal Cancer

@article{Wang2011CDH13AF,
  title={CDH13 and FLBN3 Gene Methylation are Associated with Poor Prognosis in Colorectal Cancer},
  author={Zhu Wang and Xin Yuan and Nanlin Jiao and Hongbo Jin and Youwei Zhang and Jiandong Tong},
  journal={Pathology & Oncology Research},
  year={2011},
  volume={18},
  pages={263-270}
}
The aim of this study was to identify potential epigenetic prognostic biomarkers for colorectal cancer (CRC) in the Chinese population. The methylation status of five tumor suppressor genes (CDH13, DLEC1, FBLN3, hMHL1 and RUNX3) was determined using manual microdissection followed by methylation-specific PCR in 85 paired CRC specimens and adjacent normal tissue. The results showed that methylation frequencies in cancerous tissues were 31.8% for CDH13, 37.6% for DLEC1, 38.8% for FBLN3, 22.4% for… CONTINUE READING

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Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis

S Nomoto, M Kanda, Y Okamura
Ann Surg Oncol • 2010
View 4 Excerpts
Highly Influenced

DNA methylation markers in colorectal cancer

Cancer and Metastasis Reviews • 2010
View 2 Excerpts

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