CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk.

@article{Lei2002CDH1MA,
  title={CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk.},
  author={Haixin Lei and Sara Sj{\"o}berg-Margolin and Sima Salahshor and Barbro Werelius and Eva Jand{\'a}kov{\'a} and Kari Hemminki and A. Arto Lindblom and Igor Vorechovsky},
  journal={International journal of cancer},
  year={2002},
  volume={98 2},
  pages={
          199-204
        }
}
Mutations and diminished expression of the E-cadherin gene (CDH1) have been identified in a number of epithelial malignancies. Although somatic CDH1 mutations were detected in lobular breast cancer with a frequency ranging from 10-56%, CDH1 alterations in more frequent ductal tumors appear to be rare. Here we have analyzed the coding region of CDH1 for mutations using denaturing high performance liquid chromatography and found 4 mutations in 83 ductal carcinomas (5%) and 3 mutations in 25… CONTINUE READING
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