CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

@article{Jenab2008CDH1GP,
  title={CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).},
  author={M. Jenab and James McKay and Pietro Ferrari and Carine Biessy and Stewart Laing and Gabriel Maria Capella Munar and N{\'u}ria Sala and Salvador Amado Pe{\~n}a and J. Bart A. Crusius and Kim Overvad and Majken Karoline Jensen and Anja Olsen and Anne Tjonneland and Francoise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Rudolf Kaaks and Jakob Linseisen and H. B{\"o}ing and Manuela M. Bergmann and Antonia Trichopoulou and Christina Georgila and Theodora Psaltopoulou and Amalia Mattiello and Paolo Vineis and Valeria Pala and Domenico Palli and Rosario Tumino and Mattijs E. Numans and P. H. Peeters and Hendrik Bas Bueno-de-Mesquita and Eiliv Lund and Eva Ardanaz and M P{\'e}rez S{\'a}nchez and Miren Dorronsoro and Carmen Navarro Sanchez and Jos{\'e} Ram{\'o}n Quir{\'o}s and G{\"o}ran Hallmans and Roger Stenling and Jonas Manjer and Sara R{\'e}gner and Timothy J Key and Sheila Anne Bingham and Kay-tee Khaw and Nadia Slimani and Sabina Rinaldi and Paolo A Boffetta and F{\'a}tima Carneiro and Elio Riboli and Carlos Gonz{\'a}lez},
  journal={European journal of cancer},
  year={2008},
  volume={44 6},
  pages={774-80}
}
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position -160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of… CONTINUE READING
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