• DOI:10.1182/BLOOD-2006-11-058941
Corpus ID: 9314502

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.

@article{Koschmieder2007CDDOIG,
  title={CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.},
  author={S. Koschmieder and F. D'Alo' and H. Radomska and Christine Sch{\"o}neich and J. S. Chang and M. Konopleva and S. Kobayashi and E. Levantini and N. Suh and A. Di Ruscio and M. T. Voso and J. C. Watt and R. Santhanam and B. Sargin and H. Kantarjian and M. Andreeff and M. Sporn and D. Perrotti and W. Berdel and C. M{\"u}ller-Tidow and H. Serve and D. Tenen},
  journal={Blood},
  year={2007},
  volume={110 10},
  pages={
          3695-705
        }
}

S. Koschmieder, F. D'Alo', +19 authors D. Tenen

Published 2007

Biology, Medicine

Blood

2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces differentiation and apoptosis of tumor cells in vitro and in vivo. [...] Key Result In HL60 acute myeloid leukemia (AML) cells, CDDO (0.01 to 2 muM) induces apoptosis in a dose-dependent manner. Conversely, subapoptotic doses of CDDO promote phagocytic activity and granulocytic-monocytic differentiation of HL60 cells through increased de novo synthesis of p42 CEBPA protein.Expand Abstract

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