CDDO induces apoptosis via the intrinsic pathway in lymphoid cells

@article{Inoue2004CDDOIA,
  title={CDDO induces apoptosis via the intrinsic pathway in lymphoid cells},
  author={Satoshi Inoue and R T Snowden and Martin J S Dyer and Gerald M. Cohen},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={948-952}
}
The peroxisome-proliferator-activated receptor (PPAR) γ agonist, CDDO, is under investigation for use in various malignancies. The mechanisms by which CDDO induces apoptosis are controversial. We have therefore sought to determine these mechanisms using primary chronic lymphocyte leukemic (CLL) cells and Jurkat cell lines with defined apoptotic abnormalities. In these cells, CDDO induced-apoptosis involved caspase-independent loss in mitochondrial membrane potential followed by caspase… CONTINUE READING