CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms

@article{Han2006CDDOImidazolideIG,
  title={CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms},
  author={Seong-Su Han and Liangping Peng and Seung Tae Chung and Wendy Dubois and Sung-Ho Maeng and Arthur L Shaffer and Michael B. Sporn and Siegfried Janz},
  journal={Molecular Cancer},
  year={2006},
  volume={5},
  pages={22 - 22}
}
BackgroundGene-targeted iMycEμ mice that carry a His6-tagged mouse Myc(c-myc)cDNA, MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Eμ, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell lymphoma (LBL) and plasmacytoma (PCT). Cell lines derived from Myc-induced neoplasms of this sort may provide a good model system for the design and testing of new approaches to prevent and treat MYC-driven B cell and plasma cell neoplasms in human beings. To test this… CONTINUE READING

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