CDC25A functions as a novel Ar corepressor in prostate cancer cells.

  title={CDC25A functions as a novel Ar corepressor in prostate cancer cells.},
  author={Yung-Tuen Chiu and Hui-Ying Han and Steve Chin-Lung Leung and H S Yuen and Chee-Wai Chau and Zhiyong Guo and Yun Qiu and Kwok-wah Chan and Xianghong Wang and Y. -C. Wong and Ming-tat Ling},
  journal={Journal of molecular biology},
  volume={385 2},
Androgen receptor (AR) is a ligand-dependent transcription factor and its activity is regulated by numerous AR coregulators. Aberrant expression of AR coregulators in prostate cancer cells has an important role in the development and progression of prostate cancer. We report here that CDC25A, a cell cycle-promoting phosphatase over-expressed in a number of cancers, functions as an AR coregulator suppressing the AR transcriptional activity. In this study, we found that CDC25A is upregulated in… CONTINUE READING
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