CDB-4124 does not cause apoptosis in cultured fibroid cells.

@article{Roeder2011CDB4124DN,
  title={CDB-4124 does not cause apoptosis in cultured fibroid cells.},
  author={Hilary A. Roeder and Friederike L Jayes and Liping Feng and Phyllis C. Leppert},
  journal={Reproductive sciences},
  year={2011},
  volume={18 9},
  pages={
          850-7
        }
}
OBJECTIVE Selective progesterone receptor modulators (SPRMs), such as asoprisnil (J867) and ulipristal (CDB-2914), have been shown to reduce fibroid volume in vivo and to induce apoptosis in vitro. CDB-4124 (telapristone), a SPRM with different side groups, also reduced fibroid volume in vivo, and we hypothesized that this SPRM would also cause apoptosis in cultured fibroid cells. METHODS Immortalized, progesterone receptor-positive fibroid cells, known to be capable of apoptosis, were grown… CONTINUE READING