CDART: protein homology by domain architecture.

@article{Geer2002CDARTPH,
  title={CDART: protein homology by domain architecture.},
  author={Lewis Y. Geer and Michael Domrachev and David J. Lipman and Stephen H. Bryant},
  journal={Genome research},
  year={2002},
  volume={12 10},
  pages={
          1619-23
        }
}
The Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the NCBI Entrez Protein Database based on domain architecture, defined as the sequential order of conserved domains in proteins. The algorithm finds protein similarities across significant evolutionary distances using sensitive protein domain profiles rather than by direct sequence similarity. Proteins similar to a query protein are grouped and scored by architecture. Relying on domain profiles allows CDART… CONTINUE READING

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