CD99 is a key mediator of the transendothelial migration of neutrophils.

  title={CD99 is a key mediator of the transendothelial migration of neutrophils.},
  author={Olivia Lou and Pilar Alcaide and Francis W. Luscinskas and William A Muller},
  journal={Journal of immunology},
  volume={178 2},
Transendothelial migration of leukocytes is a critical event for inflammation, but the molecular regulation of this event is only beginning to be understood. PECAM (CD31) is a major mediator of monocyte and neutrophil transmigration, and CD99 was recently defined as a second mediator of the transmigration of monocytes. Expression of CD99 on the surface of circulating polymorphonuclear cells (PMN) is low compared with expression of CD99 on monocytes or expression of PECAM on PMN. We demonstrate… CONTINUE READING
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