CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface1

@article{Sohn2001CD99RT,
  title={CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface1},
  author={Hae Won Sohn and Young Kee Shin and Im-Soon Lee and Young Mee Bae and Young Ho Suh and Min Kyung Kim and Tae Jin Kim and Kyeong Cheon Jung and Weon Seo Park and Chan-Sik Park and Doo Hyun Chung and Kwangseog Ahn and In Sun Kim and Young Hyeh Ko and Yung‐Jue Bang and Chul Woo Kim and Seong Hoe Park},
  journal={The Journal of Immunology},
  year={2001},
  volume={166},
  pages={787 - 794}
}
The down-regulation of surface expression of MHC class I molecules has recently been reported in the CD99-deficient lymphoblastoid B cell line displaying the characteristics of Hodgkin’s and Reed-Sternberg phenotype. Here, we demonstrate that the reduction of MHC class I molecules on the cell surface is primarily due to a defect in the transport from the Golgi complex to the plasma membrane. Loss of CD99 did not affect the steady-state expression levels of mRNA and protein of MHC class I… 
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