CD95 capping is ROCK-dependent and dispensable for apoptosis.

@article{Sderstrm2005CD95CI,
  title={CD95 capping is ROCK-dependent and dispensable for apoptosis.},
  author={Thomas S S{\"o}derstr{\"o}m and Sofia D Nyberg and John E. Eriksson},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 10},
  pages={
          2211-23
        }
}
Upon engagement, the CD95 receptor is rapidly clustered into cellular 'caps'. This receptor capping is one of the first events to take place following activation and it has been proposed to be important for the initiation of apoptotic signaling. As the biological roles of CD95 capping are still elusive, we explored in detail the role of capping in induction of apoptosis in lymphocytes. CD95 capping was shown to be uncoupled from apoptosis, as apoptosis could occur in the absence of CD95 capping… CONTINUE READING

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