CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation?

@article{Saas1999CD95A,
  title={CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation?},
  author={Philippe Saas and Jos{\'e} Boucraut and Anne Lise Quiquerez and Val{\'e}rie Schnuriger and Ga{\"e}lle Perrin and Sophie Desplat-j{\'e}go and D. T. Bernard and P. Roy Walker and P Y Dietrich},
  journal={Journal of immunology},
  year={1999},
  volume={162 4},
  pages={2326-33}
}
Astrocytes are a major cellular component of the brain that are capable of intense proliferation and metabolic activity during diverse inflammatory brain diseases (such as multiple sclerosis, Alzheimer's dementia, tumor, HIV encephalitis, or prion disease). In this biological process, called reactive gliosis, astrocyte apoptosis is frequently observed and could be an important mechanism of regulation. However, the factors responsible for apoptosis in human astrocytes are poorly defined. Here… CONTINUE READING
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