CD94/NKG2A inhibits NK cell activation by disrupting the actin network at the immunological synapse.

@article{Masilamani2006CD94NKG2AIN,
  title={CD94/NKG2A inhibits NK cell activation by disrupting the actin network at the immunological synapse.},
  author={Madhan Masilamani and Connie Minh-Canh Nguyen and Juraj Kab{\'a}t and Francisco Rubio Borrego and John E. Coligan},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={3590-6}
}
An adequate immune response is the result of the fine balance between activation and inhibitory signals. The exact means by which inhibitory signals obviate activation signals in immune cells are not totally elucidated. Human CD94/NKG2A is an ITIM-containing inhibitory receptor expressed by NK cells and some CD8+ T cells that recognize HLA-E. We show that the engagement of this receptor prevents NK cell activation by disruption of the actin network and exclusion of lipid rafts at the point of… CONTINUE READING

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