CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway.

@article{Muroi2009CD9RT,
  title={CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway.},
  author={Yoshikage Muroi and Toshihiro Sakurai and Akira Hanashi and Kentaro Kubota and Kentaro Nagaoka and Kazuhiko Imakawa},
  journal={Reproduction},
  year={2009},
  volume={138 6},
  pages={945-51}
}
ERVWE1 (SYNCYTIN-1), a membrane protein originating from the envelope gene of human endogenous retrovirus-W (HERV-W), mediates the fusion of mononucleated cytotrophoblasts into multinucleated syncytiotrophoblast. Though ERVWE1 has been characterized since its discovery, regulatory mechanisms associated with ERVWE1 expression have not been firmly established. We hypothesized that membrane protein CD9, involved in cell-cell fusion of fertilization and myogenesis, could be involved in the… CONTINUE READING