CD9 promotes adeno-associated virus type 2 infection of mammary carcinoma cells with low cell surface expression of heparan sulphate proteoglycans.

@article{Kurzeder2007CD9PA,
  title={CD9 promotes adeno-associated virus type 2 infection of mammary carcinoma cells with low cell surface expression of heparan sulphate proteoglycans.},
  author={Christian Kurzeder and Bernd Koppold and Georg Sauer and Stefan Pabst and Rolf Kreienberg and Helmut Deissler},
  journal={International journal of molecular medicine},
  year={2007},
  volume={19 2},
  pages={325-33}
}
Recombinant adeno-associated virus (AAV) is a promising non-pathogenic vector in the emerging field of gene therapy. For AAV serotype 2 (AAV-2) infection, experimental evidence points to an involvement of heparan sulphate proteoglycans (HSPG), but also to the existence of additional receptors. We investigated a potential role of the tetraspanin CD9 in AAV-2 infection of breast cancer cells mainly because it binds to the heparin-binding EGF-like growth factor, suggesting that it may also… CONTINUE READING