CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2.

@article{Chen2011CD83stimulatedMS,
  title={CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2.},
  author={Liwen Chen and Yibei Zhu and Guangbo Zhang and Chao Gao and Weixue Zhong and Xue-guang Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 46},
  pages={
          18778-83
        }
}
CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4(+) T-cell development in the thymus. However, its function in the peripheral immune system remains enigmatic. Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and the inhibitory effect of CD83 is mediated by monocytes. Prostaglandin E2 (PGE(2)), but not IL-10 or TGF-β, was up-regulated specifically by CD83 in monocytes. Consistent with high… CONTINUE READING

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