CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms.

  title={CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms.},
  author={Matthias Lechmann and Nicole Kotzor and Elisabeth Zinser and Alexander T. Prechtel and Heinrich Sticht and Alexander Steinkasserer},
  journal={Biochemical and biophysical research communications},
  volume={329 1},
Recently, we reported that soluble CD83 has a strong immunosuppressive activity in vitro as well as in vivo. Sequence alignment of CD83 between different species revealed the presence of five cysteines in the extracellular Ig-domain of the protein. This opens up the possibility that four cysteines are involved in the formation of two intramolecular disulfide bonds and a possible involvement of the remaining fifth cysteine in the formation of an intermolecular covalent disulfide bond, leading to… CONTINUE READING


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