CD83 expression in CD4+ T cells modulates inflammation and autoimmunity.

  title={CD83 expression in CD4+ T cells modulates inflammation and autoimmunity.},
  author={Simone Reinwald and Carsten Wiethe and Astrid M. Westendorf and Minka Breloer and Michael Probst-Kepper and Bernhard Fleischer and Alexander Steinkasserer and Jan Buer and Wiebke Hansen},
  journal={Journal of immunology},
  volume={180 9},
The transmembrane protein CD83 has been initially described as a maturation marker for dendritic cells. Moreover, there is increasing evidence that CD83 also regulates B cell function, thymic T cell maturation, and peripheral T cell activation. Herein, we show that CD83 expression confers immunosuppressive function to CD4(+) T cells. CD83 mRNA is differentially expressed in naturally occurring CD4(+)CD25(+) regulatory T cells, and upon activation these cells rapidly express large amounts of… CONTINUE READING
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