CD8 requirements for negative selection events are directly related to the TCR-antigen interaction.

Abstract

Positive selection of class I-restricted T cells has been suggested to always require the surface expression of CD8 molecules on CD4+8+ thymocytes, whilst negative selection was found to be differentially dependent, relating to the antigen being engaged by the T cell receptor (TCR). We have studied the CD8-dependency of positive and negative selection using… (More)

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Cite this paper

@article{Curnow1994CD8RF, title={CD8 requirements for negative selection events are directly related to the TCR-antigen interaction.}, author={S. John Curnow and Annick Guimezanes and Anne Marie Schmitt-Verhulst}, journal={Thymus}, year={1994}, volume={22 4}, pages={255-65} }