CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.

@article{Joetham2011CD8RT,
  title={CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.},
  author={Anthony Joetham and Masakazu Okamoto and Katsuyuki Takeda and Michaela Schedel and Hiroshi Ohnishi and Azzeddine Dakhama and Erwin W. Gelfand},
  journal={Journal of immunology},
  year={2011},
  volume={186 1},
  pages={113-20}
}
Naturally occurring CD4(+)CD25(+)Foxp3(+) T regulatory cells (nTregs) regulate lung allergic responses through production of IL-10 and TGF-β. nTregs from CD8(-/-) mice failed to suppress lung allergic responses and were characterized by reduced levels of Foxp3, IL-10, and TGF-β, and high levels of IL-6. Administration of anti-IL-6 or anti-IL-6R to wild-type recipients prior to transfer of CD8(-/-) nTregs restored suppression. nTregs from IL-6(-/-) mice were suppressive, but lost this capability… CONTINUE READING

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