CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

@article{Garcia1996CD8EF,
  title={CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes},
  author={K Christopher Garcia and Christopher A. Scott and Anders P. Brunmark and Francis Robert Carbone and Per A. Peterson and Ian A. Wilson and Luc Teyton},
  journal={Nature},
  year={1996},
  volume={384},
  pages={577-581}
}
T-CELL antigen receptors (TCR) generally interact with moderate affinity with the complex formed by major histocompatibility complex (MHC) molecules and foreign peptides1–7. MHC/TCR recognition is followed by the generation of a signal to the T cell through a monomorphic multicomponent system that includes the CD3 complex and accessory molecules such as CD4 and CD8. The interaction between the extracellular domains of MHC and TCR molecules1–7, and the interaction of MHC and CD4/CD8 molecules8… CONTINUE READING

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