CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion.

@article{Aichele2006CD8TC,
  title={CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion.},
  author={Peter Aichele and Heike Unsoeld and Marie Koschella and Oliver Schweier and Ulrich Kalinke and Smiljka Vucikuja},
  journal={Journal of immunology},
  year={2006},
  volume={176 8},
  pages={4525-9}
}
The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV… CONTINUE READING