CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.

Abstract

CD8(+) T cells are essential for controlling Trypanosoma cruzi infection. During Brazil strain infection, C57BL/6 mice expand parasite-specific CD8(+) T cells recognizing the dominant TSKB20 (ANYKFTLV) and subdominant TSKB74 (VNYDFTLV) trans-sialidase gene (TS)-encoded epitopes with up to 40% of all CD8(+) T cells specific for these epitopes. Although this… (More)
DOI: 10.4049/jimmunol.1000432

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@article{Rosenberg2010CD8TC, title={CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.}, author={Charles S. Rosenberg and Dianya L Martin and Rick L. Tarleton}, journal={Journal of immunology}, year={2010}, volume={185 1}, pages={560-8} }