CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection.

@article{Chen2001CD8TC,
  title={CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection.},
  author={Guang-Chao Chen and Premlata Shankar and Christoph Lange and Hern{\'a}n Valdez and Paul R. Skolnik and L. S.-Y. Wu and Narasimhaswamy Manjunath and Judy Lieberman},
  journal={Blood},
  year={2001},
  volume={98 1},
  pages={156-64}
}
CD8 T cells are classified as naïve, effector, or memory cells on the basis of CD45RA, CD62L, and CCR7 expression. Sequential engagement of cell-surface CD62L and CCR7 receptors is required for efficient trafficking to lymphoid tissue by means of high endothelial venules. Naïve CD8 T cells are CCR7(+)CD62L(+) CD45RA(+), whereas long-term memory cells are CCR7(+)CD62L(+)CD45RA(-). Effector cytotoxic T cells are thought to be CCR7(-)CD45RA(+). The distribution of CD8 subsets and cytolytic protein… CONTINUE READING