CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division

  title={CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division},
  author={Alessia Galgano and Aleksandr Barinov and Florence Vasseur and Jean-Pierre de Villartay and Benedita Rocha and Arthur J. Lustig},
  booktitle={PloS one},
Immune responses are efficient because the rare antigen-specific naïve cells are able to proliferate extensively and accumulate upon antigen stimulation. Moreover, differentiation into memory cells actually increases T cell accumulation, indicating improved productive division in secondary immune responses. These properties raise an important paradox: how T cells may survive the DNA lesions necessarily induced during their extensive division without undergoing transformation. We here present… CONTINUE READING
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