CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division

@inproceedings{Galgano2015CD8MC,
  title={CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division},
  author={Alessia Galgano and Aleksandr Barinov and Florence Vasseur and Jean-Pierre de Villartay and Benedita Rocha and Arthur J. Lustig},
  booktitle={PloS one},
  year={2015}
}
Immune responses are efficient because the rare antigen-specific naïve cells are able to proliferate extensively and accumulate upon antigen stimulation. Moreover, differentiation into memory cells actually increases T cell accumulation, indicating improved productive division in secondary immune responses. These properties raise an important paradox: how T cells may survive the DNA lesions necessarily induced during their extensive division without undergoing transformation. We here present… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
1 Citations
36 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 36 references

A cell cycledependent regulatory circuit composed of 53 BP 1RIF 1 and BRCA 1CtIP controls DNA repair pathway choice

  • C Escribano-Diaz, A Orthwein, A Fradet-Turcotte, M Xing, JT Young
  • Mol Cell
  • 2013

Similar Papers

Loading similar papers…