CD8 Epitope Escape and Reversion in Acute HCV Infection

  title={CD8 Epitope Escape and Reversion in Acute HCV Infection},
  author={Joerg Timm and Georg M Lauer and Daniel G. Kavanagh and Isabelle Sheridan and Arthur Y. Kim and Michaela Lucas and Thillagavathie Pillay and Kei Ouchi and Laura L. Reyor and Julian Schulze zur Wiesch and Rajesh T Gandhi and Raymond Tsang Chi Chung and Nina Bhardwaj and Paul Klenerman and Bruce D. Walker and Todd M. Allen},
  journal={The Journal of Experimental Medicine},
  pages={1593 - 1604}
In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these responses, 70-80% of individuals develop persistent infection. Although viral escape from CD8 responses has been illustrated in the chimpanzee model of HCV infection, the effect of CD8 selection pressure on viral evolution and containment in acute HCV infection in humans remains unclear. Here, we examined viral… CONTINUE READING