CD8 Epitope Escape and Reversion in Acute HCV Infection


In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these responses, 70-80% of individuals develop persistent infection. Although viral escape from CD8 responses has been illustrated in the chimpanzee model of HCV infection, the… (More)


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@article{Timm2004CD8EE, title={CD8 Epitope Escape and Reversion in Acute HCV Infection}, author={Joerg Timm and Georg M Lauer and Daniel G. Kavanagh and Isabelle Sheridan and A Y Kim and Michaela Lucas and Thillagavathie Pillay and Kei Ouchi and Laura L. Reyor and Julian Schulze zur Wiesch and Rajesh T Gandhi and Raymond Tsang Chi Chung and N Bhardwaj and Paul Klenerman and Bruce D. Walker and Todd M. Allen}, journal={The Journal of Experimental Medicine}, year={2004}, volume={200}, pages={1593 - 1604} }