CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists

@inproceedings{HernndezRuz2010CD8CO,
  title={CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists},
  author={Josel{\'i}n Hern{\'a}ndez-Ru{\'i}z and Norma Salaiza-Suazo and Georgina Carrada and Sof{\'i}a Escoto and Adriana Ruiz-Remigio and Yvonne J. Rosenstein and Alejandro Zentella and I Becker},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
Leishmania mexicana (Lm) causes localized (LCL) and diffuse (DCL) cutaneous leishmaniasis. DCL patients have a poor cellular immune response leading to chronicity. It has been proposed that CD8 T lymphocytes (CD8) play a crucial role in infection clearance, although the role of CD8 cytotoxicity in disease control has not been elucidated. Lesions of DCL patients have been shown to harbor low numbers of CD8, as compared to patients with LCL, and leishmanicidal treatment restores CD8 numbers. The… CONTINUE READING
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