CD8 + T cell response to adenovirusvaccination and subsequent suppression of tumor growth: modeling, simulation and analysis

Abstract

Using immune checkpoint modulators in the clinic to increase the number and activity of cytotoxic T lymphocytes that recognize tumor antigens can prolong survival for metastatic melanoma. Yet, only a fraction of the patient population receives clinical benefit. In short, these clinical trials demonstrate proof-of-principle but optimizing the specific… (More)
DOI: 10.1186/s12918-015-0168-9

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@inproceedings{Wang2015CD8T, title={CD8 + T cell response to adenovirusvaccination and subsequent suppression of tumor growth: modeling, simulation and analysis}, author={Qing Wang and David J. Klinke and Zhijun Wang}, booktitle={BMC Systems Biology}, year={2015} }