CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice.

@article{Heinrichs2016CD8TP,
  title={CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice.},
  author={Jessica Lauren Heinrichs and Jun Li and Hung Nguyen and Yongxia Wu and David Bastian and Anusara Daethanasanmak and M-Hanief Sofi and Steven D. Schutt and Chen Liu and Junfei Jin and Brian Betts and Claudio Anasetti and Xue-zhong Yu},
  journal={Oncoimmunology},
  year={2016},
  volume={5 6},
  pages={
          e1146842
        }
}
Adoptive natural regulatory T cell (nTreg) therapy has improved the outcome for patients suffering from graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (Allo-HCT). However, fear of broad immune suppression and subsequent dampening of beneficial graft-versus-leukemia (GVL) responses remains a challenge. To address this concern, we generated alloreactive induced Tregs (iTregs) from resting CD4(+) or CD8(+) T cells and tested their ability to suppress GVH… CONTINUE READING
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