CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.

@article{Stebbings2005CD8LD,
  title={CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.},
  author={Richard J Stebbings and Neil Berry and Herman Waldmann and Pru Bird and Geoff Hale and J. O. Stott and David C North and Robin Hull and Joanna Hall and Jenny Lines and S. I. Brown and Nikki D'Arcy and Leanne Davis and William Elsley and Cherry Edwards and Deborah Ferguson and Jane D Allen and N. W. Almond},
  journal={Journal of virology},
  year={2005},
  volume={79 19},
  pages={12264-72}
}
In order to test the hypothesis that CD8+ cytotoxic T lymphocytes mediate protection against acute superinfection, we depleted >99% of CD8+ lymphocytes in live attenuated simian immunodeficiency virus macC8 (SIVmacC8) vaccinees from the onset of vaccination, maintained that depletion for 20 days, and then challenged with pathogenic, wild-type SIVmacJ5. Vaccinees received 5 mg per kg of humanized anti-CD8 monoclonal antibody (MAb) 1 h before inoculation, followed by the same dose again on days 3… CONTINUE READING

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