CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

  title={CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.},
  author={Santhi Gorantla and Edward Makarov and Jennifer Finke-Dwyer and Catherine L. Gebhart and William Domm and Stephen Dewhurst and Howard E. Gendelman and Larisa Y Poluektova},
  journal={Journal of immunology},
  volume={184 12},
Stable engraftment of human lymphoid tissue in NOD/scid-IL-2Rgammacnull mice after CD34+ hematopoietic stem cell reconstitution permits the evaluation of ongoing HIV-1 infection for weeks to months. We demonstrate that HIV-1-infected rodents develop virus-specific cellular immune responses. CD8+ cell depletion, 2 or 5-7 wk after viral infection, resulted in a significant increase of HIV-1 load, robust immune cell activation, and cytopathology in lymphoid tissues but preserved CD4/CD8 double… CONTINUE READING
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