CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b−/− mice favoring autoimmune cholangitis

@inproceedings{Concepcion2015CD8TC,
  title={CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b−/− mice favoring autoimmune cholangitis},
  author={Axel R. Concepcion and January T. Salas and Elena Dur{\'e}ndez S{\'a}ez and Sarai Sarvide and Alex Ferrer and Ainhoa Portu and Iker Uriarte and Sandra Herv{\'a}s-Stubbs and Ronald P. J. Oude Elferink and Jes{\'u}s Prieto and Juan Francisco Medina},
  booktitle={Oncotarget},
  year={2015}
}
UNLABELLED Primary biliary cirrhosis (PBC) is a chronic cholestatic disease of unknown etiopathogenesis showing progressive autoimmune-mediated cholangitis. In PBC patients, the liver and lymphocytes exhibit diminished expression of AE2/SLC4A2, a Cl-/HCO3- anion exchanger involved in biliary bicarbonate secretion and intracellular pH regulation. Decreased… CONTINUE READING