CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system.

@article{Young2011CD8TC,
  title={CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system.},
  author={Kevin G. Young and Susanne Maclean and Renu Dudani and Lakshmi Krishnan and Subash Sad},
  journal={Journal of immunology},
  year={2011},
  volume={187 3},
  pages={1192-200}
}
After vaccination, memory CD8(+) T cells migrate to different organs to mediate immune surveillance. In most nonlymphoid organs, following an infection, CD8(+) T cells differentiate to become long-lived effector-memory cells, thereby providing long-term protection against a secondary infection. In this study, we demonstrated that Ag-specific CD8(+) T cells that migrate to the mouse brain following a systemic Listeria infection do not display markers reminiscent of long-term memory cells. In… CONTINUE READING
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…