CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice.

@article{Zellweger2014CD8TC,
  title={CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice.},
  author={Rapha{\"e}l M. Zellweger and William E. Eddy and William Weihao Tang and Robyn L. Miller and Sujan Shresta},
  journal={Journal of immunology},
  year={2014},
  volume={193 8},
  pages={4117-24}
}
Dengue virus (DENV) causes pathologies ranging from the febrile illness dengue fever to the potentially lethal severe dengue disease. A major risk factor for developing severe dengue disease is the presence of subprotective DENV-reactive Abs from a previous infection (or from an immune mother), which can induce Ab-dependent enhancement of infection (ADE). However, infection in the presence of subprotective anti-DENV Abs does not always result in severe disease, suggesting that other factors… CONTINUE READING