CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

@article{Naito1998CD8TC,
  title={CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.},
  author={Yuji Naito and Ken Saito and Ken-ich{\'i} Shiiba and Atsushi Ohuchi and Katsunori Saigenji and Hiroshi Nagura and Hideki Ohtani},
  journal={Cancer research},
  year={1998},
  volume={58 16},
  pages={3491-4}
}
The pathophysiological significance of tumor infiltrating lymphocytes remains controversial. To clarify their role, we performed clinicopathological analysis of CD8+ T cells in 131 cases of human colorectal cancer. CD8+ T cells were classified into three groups by their localization: (a) those infiltrated within cancer cell nests; (b) those distributed in the cancer stroma; and (c) those present along the invasive margin (tumor-host interface). Of these, CD8+ T cells within cancer cell nests… CONTINUE READING
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