CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1.

@article{Battistini2003CD8TC,
  title={CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1.},
  author={Luca Battistini and Laura Piccio and Barbara Rossi and Simona Bach and Simona Galgani and Claudio Gasperini and Linda Ottoboni and Donatella Ciabini and Maria Donatella Caramia and Giorgio Bernardi and Carlo Laudanna and Elio Scarpini and Rodger P McEver and Eugene C. Butcher and Giovanna Borsellino and G. Constantin},
  journal={Blood},
  year={2003},
  volume={101 12},
  pages={4775-82}
}
Multiple sclerosis (MS) is considered an autoimmune inflammatory disease of the central nervous system. Under physiologic conditions, we compared the adhesiveness of CD4+ and CD8+ lymphocytes from nontreated patients with acute, relapsing-remitting multiple sclerosis (RRMS) and from healthy donors. We show that in patients with RRMS CD8+, but not with RRMS CD4+, T cells display increased rolling and arrest in inflamed murine brain venules. Moreover, CD8+, but not CD4+, lymphocytes from MS… CONTINUE READING

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