CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses.

@article{Duijn2018CD8TC,
  title={CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses.},
  author={Janine van Duijn and Eva Kritikou and Naomi Benne and Thomas van der Heijden and Gijs H M van Puijvelde and Mara J. Kr{\"o}ner and Frank H. Schaftenaar and Amanda C. Foks and Anouk Wezel and Harm J Smeets and Hideo Yagita and Ilze Bot and Wim Jiskoot and Johan Kuiper and Bram Sl{\"u}tter},
  journal={Cardiovascular research},
  year={2018}
}
Aims T lymphocytes play an important role in atherosclerosis development, but the role of the CD8+ T-cell remains debated, especially in the clinically relevant advanced stages of atherosclerosis development. Here, we set out to determine the role of CD8+ T-cells in advanced atherosclerosis. Methods and Results Human endarterectomy samples analyzed by flow cytometry showed a negative correlation between the percentage of CD8+ T-cells and macrophages, suggesting a possible protective role for… CONTINUE READING
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