CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene.

@article{Boesen2000CD8TC,
  title={CD8+ T cells are crucial for the ability of congenic normal mice to reject highly immunogenic sarcomas induced in nude mice with 3-methylcholanthrene.},
  author={Mikael Boesen and Inge Marie Svane and April Engel and J\ogen Rygaard and Allan Randrup Thomsen and Ole Werdelin},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={121 2},
  pages={210-5}
}
An attempt was made to identify the selection pressures put upon a growing tumour by CD8+ T cells. To this end tumours induced with 3-methylcholanthrene in T cell-deficient nude mice and in congenic T cell-competent nu/+ mice were transplanted to nu/+ recipients. The rejection rate of the sarcomas from nude mice was almost twice that of the sarcomas from nu/+ mice. Depletion of CD8+ T cells from nu/+ recipients prior to transplantation made them accept nude tumours that were consistently… CONTINUE READING