CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

@article{Weiss1988CD8TC,
  title={CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.},
  author={Walter R. Weiss and Martha Sedegah and Richard L. Beaudoin and Louis H. Miller and Michael F Good},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 2},
  pages={573-6}
}
In recent malaria sporozoite vaccine trials in humans and mice, antibodies to the sporozoite coat protein have given only modest protection against sporozoite challenge. In contrast, irradiated sporozoites can protect mice against massive sporozoite infections. Evidence suggests that immunity in these mice is mediated by T cells. To identify the mechanism of immunity, we used monoclonal antibodies specific for either the CD4 or CD8 molecule to selectively deplete sporozoite-immunized mice of T… CONTINUE READING