CD8+ T-cells: function and response to HIV infection.

  title={CD8+ T-cells: function and response to HIV infection.},
  author={Naveed Gulzar and Karen F.T. Copeland},
  journal={Current HIV research},
  volume={2 1},
CD8+ T-cells are a critical component of the cellular immune response and they play an important role in the control of viral infection. During HIV infection, CD8+ T-cells are able to recognize infected cells through an MHC-I dependent process and are able to lyse cells harboring viral infection by the secretion of perforin and granzymes. These cytotoxic T-lymphocytes (CTL) can also eliminate virally infected cells through the engagement of death-inducing ligands expressed by CD8+ T-cells with… CONTINUE READING
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