CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response.

@article{Abbott2013CD8TC,
  title={CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response.},
  author={Rachel J. M. Abbott and Laura L. Quinn and Alison M. Leese and Harry M. Scholes and Annette Pachnio and Alan B. Rickinson},
  journal={Journal of immunology},
  year={2013},
  volume={191 11},
  pages={5398-409}
}
EBV elicits primary CD8(+) T cell responses that, by T cell cloning from infectious mononucleosis (IM) patients, appear skewed toward immediate early (IE) and some early (E) lytic cycle proteins, with late (L) proteins rarely targeted. However, L Ag-specific responses have been detected regularly in polyclonal T cell cultures from long-term virus carriers. To resolve this apparent difference between responses to primary and persistent infection, 13 long-term carriers were screened in ex vivo… CONTINUE READING
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