CD8+ T-cell responses against hemoglobin-beta prevent solid tumor growth.

Abstract

Bone marrow-derived dendritic cells engineered using recombinant adenovirus to secrete high levels of IL-12p70 dramatically inhibited the growth of established CMS4 sarcomas in BALB/c mice after intratumoral administration. An analysis of splenic CD8(+) T cells in regressor mice revealed a strong, complex reactivity pattern against high-performance liquid… (More)
DOI: 10.1158/0008-5472.CAN-08-0387

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