CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins.

@article{Ruhl2011CD8TR,
  title={CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins.},
  author={Marianne Ruhl and Torben Knuschke and Kevin Schewior and Lejla Glavinic and Christoph Neumann-Haefelin and Dae-In Chang and Marina B Klein and Falko Markus Heinemann and Hannelore Tenckhoff and Manfred Wiese and Peter A. Horn and Sergei O Viazov and Ulrich Spengler and Michael Roggendorf and N. Scherbaum and Jacob Nattermann and Daniel Hoffmann and Joerg Timm},
  journal={Gastroenterology},
  year={2011},
  volume={140 7},
  pages={2064-73}
}
BACKGROUND & AIMS Hepatitis C virus (HCV) acquires mutations that allow it to escape the CD8+ T-cell response, although the extent to which this process contributes to viral evolution at the population level is not clear. We studied viral adaptation using data from a large outbreak of HCV genotype 1b infection that occurred among women immunized with contaminated immunoglobulin from 1977 to 1978. METHODS The HCV nonstructural protein coding regions NS3-NS5B were sequenced from 78 patients… CONTINUE READING
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