CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138.

@article{Tey2010CD8TR,
  title={CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138.},
  author={Siok-Keen Tey and Felicia Goodrum and Rajiv Khanna},
  journal={The Journal of general virology},
  year={2010},
  volume={91 Pt 8},
  pages={2040-8}
}
Recent studies have shown that long-term persistence of human cytomegalovirus (HCMV) in mononuclear cells of myeloid lineage is dependent on the UL138 open reading frame, which promotes latent infection. Although T-cell recognition of protein antigens from all stages of lytic HCMV infection is well established, it is not clear whether proteins expressed during latent HCMV infection can also be recognized. This study conducted an analysis of T-cell response towards proteins associated with HCMV… CONTINUE READING

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