CD8+ T-cell memory in tumor immunology and immunotherapy.

  title={CD8+ T-cell memory in tumor immunology and immunotherapy.},
  author={Christopher A Klebanoff and Luca Gattinoni and Nicholas P Restifo},
  journal={Immunological reviews},
The cellular and molecular mechanisms underlying the formation of distinct central, effector, and exhausted CD8+ T-cell memory subsets were first described in the setting of acute and chronic viral diseases. The role of these T-cell memory subsets are now being illuminated as relevant to the tumor-bearing state. The generation and persistence of productive CD8+ T-cell memory subsets is determined, in part, by antigen clearance, costimulation, responsiveness to homeostatic cytokines, and CD4+ T… CONTINUE READING
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