CD8+ T-cell-mediated response to Listeria monocytogenes taken up in the liver and replicating within hepatocytes.

Abstract

Like most other organisms that enter the bloodstream, the bulk of Listeria monocytogenes injected i.v. into mice is taken up by the liver. Listeriae not killed rapidly by infiltrating neutrophils are internalized by hepatocytes which constitute the principal site of intracellular replication in the liver. CD8+ T cells play a critical role in eliminating… (More)

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