CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturation.

@article{Rau2009CD8TC,
  title={CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturation.},
  author={H P Rau{\'e} and Mark K. Slifka},
  journal={Virology},
  year={2009},
  volume={390 2},
  pages={197-204}
}
Virus-specific T cell responses are often directed to a small subset of possible epitopes and their relative magnitude defines their hierarchy. We determined the size and functional avidity of 4 representative peptide-specific CD8(+) T cell populations in C57BL/6 mice at different time points after lymphocytic choriomeningitis virus (LCMV) infection. We found that the frequency of different peptide-specific T cell populations in the spleen changed independently over the first 8 days after… CONTINUE READING

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